Disentangling penicillin resistance and compensatory adaption in pneumococci

by combining genomics and molecular microbiology

Inheritance patterns of the unitigs

This analysis investigates the hits from the GWAS analysis:

Sequences of interest

In this analysis, we investigate specific genes of interest that are potentially involved in penicillin resistance. One…

Conditional GWAS

Here we present the results of a genome-wide association study (GWAS) conducted using pyseer (John A. Lees et al. 2018), a tool for identifying genetic associations with complex traits. The GWAS using the linear mixed effects model such that the minimum inhibitory…

Penicillin binding proteins

PBPs are proteins that can attach to

β

-lactam antibiotics like penicillin. These proteins are essential for making the bacterial cell wall, and when they are bound by penicillin, the…

Serotypes, GPSC-clusters, and MLST types

The following plots presents an…

An overview of the data

The goal of this project is to determine mutations and factors that are involved in penicillin resistance. We have collected a data set with…